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Synapse vacancies induce nearby axons to compete
During development, one axon typically comes to dominate each set of synaptic sites at a neuromuscular junction. This means that just one neuron controls each muscle fiber, allowing for specificity of...
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Anthony Movshon’s opening points on the contra side of the brain mapping...
1) Scale mismatch between the synapse-synapse level and the kind of description you want to acquire about the nervous system for a particular goal. He argues that the point at which the interesting...
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Where a cortical interneuron inhibits a pyramidal cell alters its role
A nice, basic study looks at how altering the location of inhibition onto a pyramidal cell neurite affects its spiking properties. Their inhibition is meant to mimic the effects of cortical...
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What can we learn from people with severe hydrocephalus?
There are three types of experiments one can perform in neuroscience: lesions, stimulations, and recording. Obviously, a particular study can use more than one of them. The most basic natural...
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Another factor regulating synaptic strength: synaptic columns
It has been well-established for over a decade that synaptic vesicle release further away from a particular receptor cluster is associated with a decreased probability of receptor open state and...
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Traversed edges per second and brain myelination
The history of neuroscience in general, and myelination in particular, is replete with comparisons between brains and computers. For example, the first suggested function of myelin in the 1850s as an...
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Connectomics of zebrafish larvae
A nice study by Hildebrand et al. was published earlier this week, looking at the connectome of zebrafish larvae. As a reminder is what zebrafish larvae look like under the scanning microscope (this is...
View ArticleArchiving the Hayworth-Miller 2019 debate about brain preservation
In 2019, Brain Preservation Foundation president Ken Hayworth was tweeting about brain preservation as a potential medical procedure. Hayworth was asking different scientists who have commented about...
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What would “memory decoding” in the MICrONS data set imply?
Attention conservation notice: Not an area of expertise for me. Posted as in the spirit of Cunningham’s Law. The recently posted MICrONS data set has functional imaging on 75,000 pyramidal neurons and...
View ArticleHuman brain tissue can be effectively analyzed via electron microscopy at...
I recently saw this interesting quote from Kay et al 2013 in their Nature Protocols article: For tissue preparation, we have incorporated array tomography and EM preparations into routine brain bank...
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